Exploring Kidney Cancer: Causes, Symptoms and Treatments

31 Mar 2025
Exploring Kidney Cancer: Causes, Symptoms
and Treatment Breakthroughs

The Problem

Kidney cancer, or renal cancer, occurs when cells in the kidneys become abnormal and grow uncontrollably. While the kidneys play a crucial role in filtering waste and balancing fluids in the body, kidney cancer can often go undetected in its early stages due to a lack of noticeable symptoms.

In 2024, an estimated 4771 Australians will be diagnosed with kidney cancer. It remains one of the top 10 most fatal cancers in the country, affecting both men and women, although men are at a higher risk.

There are several types of kidney cancer, with the most common being renal cell carcinoma (RCC), which accounts for about 85% of cases. RCC begins in the cells lining the small tubes of the kidneys and often spreads to other parts of the body. Another type is transitional cell carcinoma, which starts in the renal pelvis, the area where the kidney connects to the ureter. Wilms tumour is a kidney cancer that primarily affects children.

Although the risk of kidney cancer generally increases with age, it can affect people at any stage of life. Factors such as smoking, obesity, hypertension, and a family history of kidney cancer contribute to the development of the disease. In some cases, genetic mutations are also found to increase the likelihood of developing kidney cancer.

 

Kidney Cancer Statistics (Australia) 2022

Statistic

Figure

Estimated number of new cases (2022)

4552

Proportion of all new cancer cases

2.8%

Estimated number of deaths (2024)

912

Five-year survival rate

81%

People living with kidney cancer (2013–17)

14,469

*Source: Cancer Australia, Australian Government Department of Health

Kidney Cancer Statistics (Australia) 2024

Estimated number of new cases                             4771

Average age of diagnosis                                         65

Ranking of commonly diagnosed cancers             7th

*Source: Cancer Council

Breaking Down Barriers

One of the major obstacles in combating kidney cancer is its tendency to be diagnosed at later stages, when it is harder to treat. Many kidney tumours are asymptomatic or present only vague symptoms, which means that regular screening is not typically performed.

While surgery can often remove localised tumours, advanced cases of kidney cancer require other treatments, such as targeted therapies, immunotherapy, or chemotherapy. However, progress in treatment is ongoing, and new therapies are providing patients with more hope for managing their condition and improving outcomes.

Breakthroughs in immunotherapy, which harnesses the body’s immune system to fight cancer cells, have shown promise for advanced kidney cancer cases, particularly for patients who have not responded to traditional treatments.

A Survivor’s Story: Meet Lee

Lee Hobbins, a grateful patient of PA Hospital, is turning his love for the board game Blood Bowl into a fundraising event to thank those who have cared for him throughout his battle with renal cell carcinoma. Lee was first diagnosed in 2015 after seeking help for what he thought was a hernia, only to learn that the swelling was caused by tumours in both of his kidneys. The news was a shock, and after initial consultations elsewhere, he was referred to the PA Hospital where Dr. Simon Woods was able to save part of one kidney with a successful surgery.
Lee's journey wasn't easy. Following the surgery to remove one kidney, he faced a further challenge when the cancer metastasized to his adrenal gland in 2016, requiring another major surgery. Over the years, Lee remained vigilant with regular scans and even returned to work as a nurse. But in 2020, at the five-year mark, he received the devastating news that three new lesions had appeared, including one in his pancreas.
Despite these setbacks, Lee was placed on an immunotherapy trial at PA Hospital, which has successfully kept his lesions at bay for two years. The trial has allowed him to live a better quality of life, prompting Lee to give back. He decided to host a Blood Bowl tournament to raise funds for the PA Research Foundation, aiming to show his gratitude for the care he has received throughout his journey.
Lee is now looking forward to the Blood Bowl tournament on May 7 at Chermside Library, where he hopes to raise funds through raffles and the tournament itself. This event marks not only his love for the game but his desire to give back to the hospital that has supported him through his eight-year battle with cancer.
Lee Hobbins (above right) with his family.

Advancing Research and Saving Lives

PARF continues to invest in research that will change the future of kidney cancer treatment. Some of the key areas of focus include:
  • Genomic Medicine: By studying the genetic makeup of kidney tumours, researchers can develop personalised treatment plans that target the specific mutations in a patient’s cancer cells.
  • Immunotherapy Advancements: New therapies designed to boost the body’s immune response are providing hope for patients who once had limited treatment options.
  • Early Detection Innovations: Researchers are developing blood and urine tests that could detect kidney cancer earlier, offering patients a greater chance of successful treatment.
  • Less Invasive Procedures: Minimally invasive treatments, including advanced surgeries and cryotherapy, are helping reduce recovery times and improve patient outcomes.
A Future Without Kidney Cancer
While the journey to overcome kidney cancer remains ongoing, there is hope for a brighter future. With continued investment in research, better diagnostic tools, and more effective therapies, we are closer than ever to improving the survival rates and quality of life for kidney cancer patients.
The collective effort from researchers, clinicians, and supporters like you is making a difference. By funding research and supporting clinical trials, we are paving the way for more breakthroughs and ultimately a future where kidney cancer is no longer a leading cause of death.